Chinese Medicine. International Journal of Green Pharmacy. Moraceae leaf methanolic extract Gregory, M. American Journal of Pharmacology and Toxicology. Top cited articles. Users Online : Editorial Board.
Ahead of print. Current Issue. Miscellaneous plants. Article Tables. Year : Volume : 38 Issue : 2 Page : How to cite this article: Dharmani P, Palit G. Exploring Indian medicinal plants for antiulcer activity. Indian J Pharmacol ; Indian J Pharmacol [serial online] [cited Jan 14]; Valle DL.
Peptic ulcer diseases and related disorders. Harrison's principles of internal medicine. New York: McGraw-Hill; Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophageal reflux disease. New York: Mc Graw-Hill; Biochemical studies on the antiulcerogenic activity of cauvery , an ayurvedic formulation in experimental ulcers.
The evolving role of natural products in drug discovery. Nature Rev Drug Discov ; Allophylus serratus : a plant with potential anti-ulcerogenic activity. J Ethnopharmacol ; Desmodium gangeticum : A plant with potent anti-ulcer effect. Indian J Exp Biol ; Evaluation of anti-ulcerogenic and ulcer healing properties of Ocimum sanctum Linn.
Anoop A, Jegadeesan M. Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R. Antiulcerogenic effect of ethanolic extract of Emblica officinalis : An experimental study. Effect of Convolvulus pluricaulis Chois on gastric ulceration and secretion in rats. Indian J Exp Biol ; Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. Gastroduodenal ulcer protective activity of Asparagus racemosus : an experimental, biochemical and histological study.
Ocimum sanctum : An experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals.
Singh S, Majumdar DK. Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum Holy Basil. Bhargava KP, Singh N. Anti-stress activity of Ocimum sanctum Linn. Indian J Med Res 1 ; Chronic oral administration of Ocimum sanctum Linn. J Pharm Pharmacol ; Effect of Ocimum sanctum leaf powder on blood lipoproteins, glycated protein and total amino acids in patients with non-insulin-dependent diabetes mellitus. J Nutr Environ Med ; Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action.
Ocimum sanctum Linn- a study on gastric ulceration and gastric secretion in rats. Indian J Physiol Pharmacol ; Mucosal repair and COX-2 inhibition. Current Pharma Design ; Gupta AK, Tandon N. Reviews on Indian Medicinal Plants. Micro sponges are patented polymeric drug delivery systems consisting of porous microspheres.
The physical appearance of microsponges is tiny spherical sponge-like with the surface with large spores. Micro sponges are typically used and nowadays used as the oral dosage form. The inert and indestructible tiny spherical particles do not pass through the skin. But, it collects in the tiny nooks and c Patients and Methods: We made this study on subjects men divided into four groups 30 healthy control Seaweeds are potential sources of bioactive molecules.
They are known to be rich sources of proteins, carbohydrates, lipids, vitamins, minerals, and other secondary metabolites. To evaluate the presence of these compounds in marine macroalgae collected from Veraval coast of Gujarat, present studies was carried out. The methanol extract of six macroalgae species Ulva lactuca, Ulva faciata, Acantho Topical formulations may contribute to the reduction of oxidative stress in the skin.
Banana peel is a fruit waste with antioxidant activity that is not yet included in a topical formulation. The aim of this study was to evaluate the antioxidant and anti-aging activity of a cream formulation containing a lyophilized extract of banana peel. The banana peel was extracted with ethanol, and a cream fo Fruit is a drupe, yellowish white or pinkish, ovoid, 10 to 13 mm long with a rather scanty pulp and a hard stone.
The persistent calyx in the fruit is broadly funnel-shaped, enlarged and about 8 mm diameter. Distribution: Throughout the Philippines. Common in secondary forests and thickets and low and medium altitudes. Bark contains a large amount of tannic acid. Fruit pulp contains sugar, gum, extractive matters and ash. Fruit is considered demulcent; the bark, astringent and tonic. Uses: The bark is moistened and applied to boils and tumors to hasten ripening. Also used for headaches and stomach aches.
Bark is used as antidyspeptic and as febrifuge. Powdered bark is used for mouth ulcers. Infusion of bark is used as gargle. The bark juice, mixed with coconut milk, is used to relieve colicky pains. The barks are rubbed on the teeth to strengthen them. Leaves are used for ulcers and headaches. The highly mucilaginous fruit is used for coughs and ailments of the chest, uterus and urethra.
In large quantities, used as a laxative. From this study, it is clear that the medicinal plants play a vital role against various diseases. Various herbal plants and plants extracts have significant antiulcer activity in animal models. It has muco-protective activity and gastric anti-secretary when compared with that of reference drugs. The extract is non-toxic even at relatively high concentrations. The antiulcer activity is probably due to the presence of flavonoids in all this plants.
Our results showed that above-mentioned medicinal plants could prevent ulcer in rats in a dose-dependent manner. A variety of botanical products have been reported to possess antiulcer activity; finally, it should be noted that substances such as flavonoids, and tannins that possess antiulcer activity are of particular therapeutic importance.
The results of this study indicate that extracts of leaves and plants extracts of some medicinal plant have good potentials for use in peptic ulcer disease. Our results showed that these medicinal plants could prevent ulcer in rats in a dose-dependent manner. The present study was designed to explore the mechanism of action of medicinal plants against experimentally induced gastric ulcers.
The bark extracts were tested against aspirin- and ethanol-induced gastric ulcer models and histamine infusion-induced gastric acid secretion model in rats. It is concluded from this study that the drug possesses antiulcer activity in different gastric ulcer models.
The antiulcer activity of the drug can be attributed to free-radical scavenging property, inhibition of acid secretory parameters and strengthening of gastric mucosal barrier. Source of Support: Nil. Conflict of Interest: None declared. National Center for Biotechnology Information , U. Journal List Pharmacogn Rev v. Pharmacogn Rev.
Gadekar , P. Singour , P. Chaurasiya , R. Pawar , and U. Author information Article notes Copyright and License information Disclaimer. Address for correspondence: Dr. E-mail: moc. Received Mar 25; Revised Mar This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC.
Abstract Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. Keywords: Alkaloids, antiulcer activity, flavonoids, peptic ulcer, saponin, tannins. The potential medicinal plants used in ulcer In spite of being one of the well-known medicinal plants used inIndian traditional medicine to treat several ailments, studies pertaining to the pharmacologicalproperties of some medicinal plants are very scarce.
Some medicinal plants used in the treatment of ulcer:. Chemical structure [ Table 1 , Scheme 1 ] Table 1 Some potential plants with antiulcer activity[ 2 ].
Open in a separate window. Scheme 1. Alstonia Scholaris R. Local name: Saptaparna Family: Apocynaceae Classification: Kingdom: planate Order: Gentianales Genus: Alstonia Description: Alstonia devil tree consists of about 40—60 species native to tropical and subtropical with most species in the Malaysian region. Chemical structure [ Scheme 2 ]. Scheme 2. Asparagus racemosus Willd Local name: Satawari, satavari.
Habitat: The plant grows best in tropical and subtropical dry and deciduous forests. Part used: Shoots and tuberous roots. Scheme 3. Azadirachta indica Juss. Melia azadirachta L. Botanical name: Azadirachta indica Family: Meliaceae Common names: Neem, nim, Indian lilac, nimmi, limbo, limda Part used: leaves, flower, oil and seed.
Habitat: It is evergreen and grows throughout India. The most common ones are:[ 14 — 16 ] Azadirachtin : Provides repellent, anti-hormonal and anti-feedant properties Nimbin: Provides anti-inflammatory, antipyretic, antihistamine and antifungal properties Nimbidin: Provides antibacterial, antiulcer, analgesic, antiarrhythmic and antifungal properties Nimbidol: Provides antitubercular, antiprotozoan and antipyretic properties Sodium nimbinate: Provides diuretic, spermicidal and antiarthritic properties Quercetin: Provides antiprotozoal, antioxidant, antiinflammatory and antibacterial properties Neem seed oil contains the major concentrations of these active compounds along with many fatty acids like oleic acid, stearic acid, palmitic acid, linoleic acid and so on.
Chemical structure [ Scheme 4 ]. Scheme 4. Bauhinia variegata Linn. Chemical structure [ Scheme 5 ]. Scheme 5. Quercetin[ 19 ]. Flavonoid[ 4 ] Uses: The bark is astringent, tonic and anthelmintic. Butea frondosa Roxb. Chemical Structure [ Scheme 6 ]. Scheme 6.
Carica papaya L. Species: Carica papaya L. Scheme 7. Species: Annona squamosa L. Chemical constituents Bark contains a large amount of tannic acid. Chemical structure [ Scheme 8 ]. Scheme 8. Grossman M. Am J Pharm Toxicol. Chicago: Year Book Medical Publishers; Peptic ulcer: A guide for the practicing physician; p. Pune: Nirali Prakashan Publisher; Indian medicinal plants: A compendium of species. Hyderabad: Orient Longman Publisher; Parmar NS, Parmar S.
Anti-ulcer potential of flavonoids. Indian J Physiol Pharmacol. Molecular weight, structure and shape of oat , -b-D-glucan fractions obtained by enzymatic degradation with -b-D-glucan 4-glucanohydrolase from Trichoderma reesei , carbohydrates.
Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus. A textbook of Pharmacognosy. London: Bailliere Tindall Ltd; Cook NC, Samman S. Flavonoids-chemistry, metabolism, cardio protective effects and dietary sources. Nutr Biochem. Frankel E. International conference on food factors: Chemistry and cancer prevention.
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